RETRACTED ARTICLE: In situ structural characterization of early amyloid aggregates in Alzheimer’s disease transgenic mice and Octodon degus

Recollection of What-where-which Memory in Degus (octodon Degus)

To examine if a feature of episodic-like memory reported in rats is shared with other species, we investigated whether degus would form an integrated memory of object (what), place (where), and context (which). We used two E-shaped mazes with different contexts regarding the wall and the floor. Degus were entered into the middle arm and first explored the maze with two trial-unique objects plac...

Early Olfactory Environment Influences Social Behaviour in Adult Octodon degus

We evaluated the extent to which manipulation of early olfactory environment can influence social behaviours in the South American Hystricognath rodent Octodon degus. The early olfactory environment of newborn degus was manipulated by scenting all litter members with eucalyptol during the first month of life. The social behaviour of sexually mature animals (5-7 months old) towards conspecifics ...

Título Artículo / Títol Article: Octodon Degus: a Model for the Cognitive Impairment Associated with Alzheimer's Disease Octodon Degus: a Model for the Cognitive Impairment Associated with Alzheimer's Disease

Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concerned with neurodegenerative diseases in which risk is associated with ageing. O...

Effects of hyperoxia in alzheimers transgenic mice

Revisiting rodent models: Octodon degus as Alzheimer’s disease model?

Alzheimer's disease primarily occurs as sporadic disease and is accompanied with vast socio-economic problems. The mandatory basic research relies on robust and reliable disease models to overcome increasing incidence and emerging social challenges. Rodent models are most efficient, versatile, and predominantly used in research. However, only highly artificial and mostly genetically modified mo...